Anti Hypertensive Activity of the Ethanolic Extract of Lantana camara leaves on high salt loaded wistar albino rats

In an attempt to scientifically evaluate the antihypertensive activity of etanolic extract of Lantana camara in different experimental models. Anti hypertensive activity of EELC was evaluate by frog heart, anaesthetic chick and salt induced rat model. EELC produced negative inotropic and negative chronotropic effect, antagonised by atropine on isolated frog heart. EELC shows dose dependent (p<0.05) decreased mean arterial blood pressure (MABP) an anaesthetic chick. salt treated rats displayed significant (p<0.05) increase in blood level of SGOT,SGPT, Creatinine and sodium, decreases in pottassim levels compare than normal rats. Treatment of EELC (200 and 400 mg/kg) significantly balanced the ionic levels, such as lower the sodium and elevate the potassium levels. Creatinine levels were significantly (p<0.05) reduces by the treatment of EELC. These are no significant changes occurred in serum SGOT and SGPT with the treatment of EELC. The present study suggest that treatment of EELC on Salt hypertensive rats protects against renal injuries maintaining the normal ionic composition as well as parameters.

Key words: EELC (ethanolic extract of Lantana camara leaves), Wistar albino rats, Hypertension, mean arterial blood pressure (MABP) and normotensive rats (NTR).