ArticleViewAbstractPharmacognosy Journal,2015,7,4,228-235.Published:29th Apr, 2015Type:Original ArticleHepatoprotective Activity of Michelia nilagirica against Paracetamol Induced Hepatic Injury in RatsShaik Aminabee, Atmakuri Lakshmana Rao, and Maram Chinna Eswaraiah Shaik Aminabee1, Atmakuri Lakshmana Rao*1 and Maram Chinna Eswaraiah2 1Department of Pharmacology, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, INDIA2Department of Pharmacognosy, Anurag College of Pharmacy, Kodad, Telangana, INDIA.Abstract:Background:Michelia nilagirica belonging to the family Mangoliaceae is commonly used by many traditional healers in most of the herbal preparations for diabetes and kidney diseases. Objective: Different fractions isolated from ethanolic extract of whole plant of Michelia nilagirica is investigated for hepatoprotective activity in wistar albino rats against paracetamol induced hepatic injury. Materials & Methods: Rats were divided into eight groups. Each group contains six animals. Hepatic injury was achieved by injecting paracetamol at a dose of 2 mg/kg p.o. Results: The hepatoprotective action is seen with fraction A by reduction in serum marker enzymes like Aspartate transaminase (AST), Alanine transaminase (ALT). It also reduced the elevated levels of Alkaline phosphotase (ALP) & Serum bilirubin. Conclusion: Histopathological studies further confined the hepatoprotective activity of fraction A against paracetamol treated group. The results obtained were compared with silymarin (100 mg/kg, orally), a standard drug.Key words: Albino rats, Hepatoprotective, Michelia nilagirica, Paracetamol, Screening.Keywords:Albino rats, Hepatoprotective, Michelia nilagirica, Paracetamol, Screening.