ArticleViewAbstractPharmacognosy journal,2014,6,3,62-71.Published:8th April 2014Type:Original ArticleAnti-diabetic, Hypolipidemic and Anti-oxidant Activities of Hydroethanolic Root Extract of Rhus Mysurensis Heyne in Streptozotocin Induced Diabetes in Wistar Male RatsSanwar Mal Lamba, Kunjbihari Sulakhiya, Parveen Kumar, Mangala Lahkar, Chandana C. Barua, and Babul Bezbaruah Sanwar Mal Lamba1#, Kunjbihari Sulakhiya1#, Parveen Kumar1#*, Mangala Lahkar2, Chandana C. Barua3 and Babul Bezbaruah21Laboratory of Molecular Pharmacology and Toxicology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), GMC IIIrd Floor, Bhangagarh, Guwahati- 781032, India2Laboratory of Pharmacology, Department of Pharmacology, Gauhati Medical College, Bhangagarh, Guwahati-781032, India3Department of Pharmacology & Toxicology, College of Veterinary Sciences, Khanapara, Guwahati-781022.Abstract:Objectives: The present study was designed to investigate the potential role of hydroethanolic root extracts were Rhus mysurensis (HERM) in the treatment of diabetes along with its antioxidant and antihyperlipidemic effects was studied in streptozotocin induced diabetes in Wistar rats. Methods: In this study, the anti-diabetic, hypolipidemic and anti-oxidant activities of hydroethanolic root extract of Rhus mysurensis was evaluated by using STZ induced diabetic rats at a dose of 200 mg/kg, 400 mg/kg and 800 mg/kg p.o. daily for 21 days. Blood glucose levels and body weight were monitored at specific time intervals, and different biochemical parameters, serum cholesterol, serum triglyceride, high density lipoprotein, low density lipoprotein were also assessed in the experimental animals. Results: Oral administration of hydroethanolic root extracts of Rhus mysurensis (HERM) 400 and 800 mg/kg for 21 days significantly decreased the blood glucose level and considerably increased the body weight of diabetic induced rats. Daily oral treatment with HERM for 3 weeks resulted in reduced serum cholesterol, and triglycerides and improved HDL-cholesterol levels when compared to the diabetic control group. HERM significantly decreased thiobarbituric acid reactive substances (TBARS) and significantly increased superoxide dismutase and catalase in streptozotocin-induced diabetic rats at the end of 21 days of treatment. Conclusion: Hydroethanolic root extract of Rhus mysurensis showed significant anti-diabetic, hypolipidemic and anti-oxidant activities, which provide the scientific proof for its traditional claims. The results also put forward that the HERM is promising for development of standardized phytomedicine for the treatment of diabetes mellitus.Key words: Anti-diabetic, anti-oxidant, hypolipidemic, Rhus mysurensis.Keywords:Anti-diabetic, Anti-oxidant, Hypolipidemic, Rhus mysurensis.